Roya Dolatkhah
Tabriz University of Medical Sciences, Iran
Title: Are dietary, life style and socio-economic factors associated with the risk of mutations in colorectal cancer?
Biography
Biography: Roya Dolatkhah
Abstract
Background & Aim: There are known factors having an etiological role in colorectal cancer, however few studies have addressed how and to what extent these factors affect the genetics and the disease processes. The precise relationship between these risk factors and specific genetic mutations that could alter signaling pathways involved in colorectal cancer is unknown. This study aimed to investigate any relationships between lifestyle, dietary habits and socio-economic factors and the risks of KRAS and BRAF mutations in colorectal cancer patients.
Methods: Patients with definitive diagnosis of colorectal cancer were included. The presence and type of the point mutations for KRAS exon 2 and BRAF exon 15 were determined by Sanger sequencing method. Logistic regression was employed to investigate the association of specific mutations involved in colorectal cancer and life style factors, patterns of food consumption
and socioeconomic status.
Results: In this study, the rate of the KRAS mutation was 26% and the most prevalent mutation type was in codon 12. High socio-economic status was significantly associated with higher likelihood of KRAS gene mutation (P<0.05) (OR: 3.01; 95% CI: 0.69-13.02). Findings suggest consuming carbohydrates and alcohol increased odds of KRAS mutation. Patients with less working times and more common sedentary life style were more likely to have mutant KRAS gene.
Conclusions: Improving control and prevention of the risk factors, which affect the incidence of specific mutations can help in enhancing the prognosis of colorectal cancer in affected patients and in designing family-based prevention programs.