3rd Annual Conference on Gynecologic Oncology & Preventive Oncology July 20-21, 2017 Chicago, Illinois, USA

Biography:

Aaron H Chevinsky is the Director of Surgical Oncology at Aurora Health Care in Wisconsin. He has lectured nationally and internationally and has published on many aspects of cancer care. He attended medical school and completed his surgical residency in New York, and completed a surgical oncology fellowship at Ohio State. He has been named to the Top Docs list and has won awards for the development of multidisciplinary cancer care programs. He also appeared on TV and radio to raise awareness and promote cancer screening he remains committed to providing the best cancer care to the patients he treats.

Abstract:

Nanoknife Irreversible Electroporation is a locally based treatment for unresectable cancers, particularly those close to major vascular structures.  Using DC electrical current, small pores are created in the cellular membrane allowing extracellular fluid to enter and rupture the cell.  This is accomplished without damage to the underlying vessels and ducts in the vicinity.  In contradistinction to heat based ablative therapies such as radiofrequency and microwave ablation, there is no heat-sink effect which increases the rate of recurrence near major vascular structure.  This procedure has been primarily used for locally advanced tumors of the pancreas involving the superior mesenteric artery and/or vein or the celiac artery, and tumors of the liver near the major hepatic veins, inferior vena cava or portal veins.  It has also been successfully used in tumors of the head and neck, lung, retroperitoneum, kidney and prostate.  Martin et al (1) documented a doubling in survival in patients with locally unresectable pancreatic cancers from under 12 months (historical controls) to 24.9 months.  This procedure can be done both as an open surgical procedure and percutaneously by interventional radiology.   Nanoknife therapy provides a safe alternative therapy for patients with previously unresectable disease in the liver and pancreas.   With a short follow up, we have demonstrated effective local control.  Longer follow up and larger series are needed.

Aurora Health Care system has become the first site in Wisconsin to offer this new technology.  The procedural details, indications, patient selection and precautions will be presented along with case studies of patients undergoing this procedure.

Biography:

Joseph O Nwankwo obtained his DPhil from Oxford University and Post-doctoral/Research fellowships at University of Southern California and University of Iowa. He was also an Associate Scientist at the University of Wisconsin, Madison Department of Surgery and the Cancer Centre. He was the pioneer Director of the Centre for Molecular Biosciences and Biotechnology, Michael Okpara University of Agriculture, Umudike, Nigeria and currently, the Head of Department of Medical Biochemistry at the Federal University, Ndufu-Alike, Ikwo, Nigeria. He has published more than 25 papers in reputed journals.

Abstract:

Many indigenous west African plants have been employed as local remedies for various human ailments in the traditional medicine of the region and as nutritional sources for countless generations. Isolation and characterization of the chemical structures for phytochemicals from useful indigenous plants have however been undertaken only for a minimal fraction largely, because the modern techniques of chromatography and mass spectroscopy have been exploited by African scientists relatively, recently. The significance of the latter development has been to greatly enhance an understanding of the molecular mechanisms of action for these isolated compounds as pharmacological agents. In particular, such knowledge has been applied in the present discussion to identify indigenous west African phytochemicals with potential anticancer activities based on their structure-activity relationships to known active compounds – an outcome totally unanticipated by the organic chemists who merely isolated and characterized these phytochemicals. The compounds are grouped as potential “Cancer Chemopreventive” and “Cancer Chemotherapeutic” agents and cover most of the known phytochemical classes of alkaloids, flavonoids, lignans, quinones, terpenoids and ‘miscellaneous’, the latter class comprising compounds considered chemically inappropriate for the previous classes. Such identified compounds still await relevant biological activity tests before confirmation of suggested anticancer potentials. 

Biography:

Zaid Al-Wahab has completed his Medical Degree from Al-Nahrain University. He has completed his residency in Obstetrics and Gynecology from Wayne State University/Detroit Medical Center. He then did a Fellowship in Gynecologic Oncology from Karmanos Cancer Institute/Wayne State University. His interest lies in minimally invasive surgery including Robotic Surgery and Sentinel lymph node mapping.

Abstract:

Cancer is an important cause of death in women of childbearing age. Cancer incidence in pregnancy has increased in the last 50 years due to higher rates of cancer and delay in childbearing. There are more than 800,000 women receive cancer diagnosis every year and 4 million women who will become pregnant in the US each year. The most common cancers in pregnancy are Breast and Cervical cancers. Symptoms of cancer can be confounded with pregnancy symptoms. The diagnosis and treatment require a balance of risks and benefits for both maternal and fetal wellbeing. This requires a multidisciplinary approach of different specialties. Management of cancer with surgery, chemotherapy, radiation and hormonal therapy depend on the gestational age, stage of disease and the specific type of treatment. As advancements in cancer treatments continue to improve survival, increased focus has been given to improvement in quality of life for survivor. Onco-fertility is a fast growing field that focuses on fertility preservation for the patients after cancer treatment. Options for women to have children after cancer have increased significantly in recent years. 

Biography:

Shaila Anwar working in the Department of Obstetrics and Gynecology of Ghurki Trust Teaching Hospital, Pakistan. She has published many papers in reputed journals

Abstract:

Objectives: To find out pelvic and paraaortic lymph node enlargement with clinical stage of carcinoma of cervix; and also to see the histopathological correlation with lymph node enlargement.

Duration: June 2004 to May 2016.

Place of Study: Department of Obstetrics & Gynecology, Department of Radiotherapy and Department of Radiology Ghurki Trust Teaching Hospital and Mayo Hospital, Lahore.

Method: 115 patients were clinically staged and evaluated by CT. Treatment record of radiotherapy was available.

Results: Paraaortic and pelvic lymph node involvement was seen to be increasing with advancing stage of carcinoma of cervix. Highest lymphatic involvement was seen with SCK type of histopathology.

Conclusion: With SCK tumor and advanced stage of disease, radiation fields may need to be modified to include lymph nodes in para aortic region. More studies need to be conducted in this area

Biography:

Nabeela Shami working in the Department of Obstetrics and Gynecology of Lahore Medical & Dental College, Pakistan. She has published many papers in reputed journals.

Abstract:

Background: Secondary cytoreductive surgery should be considered in all patients with recurrent epithelial ovarian cancer as optimal secondary cytoreduction has been associated with improved survival, irrespective of duration of disease free interval (DFI). A good performance status, initial optimal cytoreduction and absence of ascities are suggestive of increased odds of optimal secondary cytoreduction. Extent of disease is also a major determinant as patients with smaller disease burden are more likely to achieve optimal cytoreduction. Consequently, delay in secondary cytoreduction may reduce the number of patients who can undergo optimal cytoreduction. As yet, there is no consensus in literature regarding the optimum timing of secondary cytoreduction in patients with recurrent disease. The present series aims to document the success rate of optimal secondary cytoreduction in patients based on their DFI.

Methods: Patients who had undergone primary cytoreductive surgery, had received chemotherapy and showed a complete response, but subsequently presented with disease recurrence, were included. Evidence of measurable disease on imaging study was required. Abdomen was opened with a vertical incision, ascitic fluid/washings were removed, maximal cytoreduction was performed with a goal to reduce the tumor to <1 cm diameter. All patients were given gemcitabine 1250 mg/m2 on day 1 and 8 and cisplatin 70 mg/m2on day 1 only. Cycles were repeated every three weeks. RECIST was used for response evaluation.

Result: One hundred and eight patients were enrolled from December 1998 to December 2013. Median age was 52 years (range 40-68). Seventy two patients had previously received cyclophosphamide and cisplatin while 36 had received paclitaxel and carboplatin. The disease free interval was less than 6 months in 32 patients, more than 6 months in 50 patients and more than 12 months in 26 patients. Optimal cytoreduction was achieved in 42 (38.8%) patient only and included 15, 20 and 7 patients with DFI of <6 months, >6 months and >12 months, respectively. Gut injury was seen in 8 (7.4%) and bladder perforation in 8 (7.4%). Among 42 patients with optimal cytoreduction, 20 had a CR while 22 showed a PR with chemotherapy whereas in patients with sub-optimal surgery CR was seen in 14 patients, PR in 20 and less than PR in 32 patients.

Conclusion: Secondary cytoreduction and postoperative second line chemotherapy with gemcitabine and cisplatin is a reasonable treatment option for patients with recurrent epithelial ovarian cancer. Early cytoreduction seems to confer a favorable surgical outcome. The present data suggests that early detection and surgical intervention of recurrent disease may result in increased response rates. Further studies are needed to validate our findings in larger patient cohorts.

Biography:

Marta Recio Rodríguez has completed her Medical studies in Universidad Complutense de Madrid (Spain) and continued her foundation for 4 more years with the National Medical Residency System to specialize in Gynecology and Obstetrics. She also has 2 Master degrees, the first one in Sexology and couples therapy, and the second one in Urogynecology and pelvic floor dysfunctions. She is the Coordinator Manager of the Gynaecological and Obstetrics team in Policlinica Nuestra Señora del Rosario in Ibiza and also a Member of the Breast Pathology Unit.

Abstract:

Being diagnosed with gynecological or breast cancer implies confronting the organic and psychological consequences of an illness that affects parts of the body which are full of sexual significance. Together with the actual process of the cancer, the medical and surgical treatments received can cause severe consequences on the patients’ sexuality, including body image and self-esteem. It is the duty of the medical professionals to include a sexual assessment of oncology patients as an integral part of the medical evaluation. The aim of this talk is to deal with the different physical and psychological issues in oncological patients’ sexuality and their correct management. 

Biography:

Abstract:

Biography:

Muhammad Ibrar Khan Afridi is currently working Near East University, Turkey. He has published many papers in reputed journals.

Abstract:

Adipogenesis refers to the differentiation of pre-adipocytes into mature fat cells, i.e., the development of adipose tissue, which varies according to sex and age. Adipocytes differentiate from stellate or fusiform precursor cells of mesenchymal origin. Adiponectin has been postulated to act an important role in the modulation of glucose and lipid metabolism in insulinsensitive tissue in both humans and animals. The transition from pre to post menopause is associated with the emergency of many features of metabolic state. The intraabdominal body fat increases, low density lipoprotein and triglyceride levels increase while high density lipoprotein decreases, as the results to date are conflicting. In this study, we aimed to study the changes in adiponectin and anthropometric parameters after menopause. For the purpose, the ELISA method was used in the study to evaluate the values of adiponectin. A total of 70 female in menopause and 90 control subjects were included in this study. The results showed that adiponectin, BMI and blood pressure increased with menopause. It is recommended that further work must be carried out in the near future in order to investigate the effect of menopause on these parameters.

Biography:

Aaron H Chevinsky is the Director of Surgical Oncology at Aurora Health Care in Wisconsin. He has lectured nationally and internationally and has published on many aspects of cancer care. He attended medical school and completed his surgical residency in New York, and completed a surgical oncology fellowship at Ohio State. He has been named to the Top Docs list and has won awards for the development of multidisciplinary cancer care programs. He also appeared on TV and radio to raise awareness and promote cancer screening he remains committed to providing the best cancer care to the patients he treats.

Abstract:

Nanoknife Irreversible Electroporation is a locally based treatment for unresectable cancers, particularly those close to major vascular structures.  Using DC electrical current, small pores are created in the cellular membrane allowing extracellular fluid to enter and rupture the cell.  This is accomplished without damage to the underlying vessels and ducts in the vicinity.  In contradistinction to heat based ablative therapies such as radiofrequency and microwave ablation, there is no heat-sink effect which increases the rate of recurrence near major vascular structure.  This procedure has been primarily used for locally advanced tumors of the pancreas involving the superior mesenteric artery and/or vein or the celiac artery, and tumors of the liver near the major hepatic veins, inferior vena cava or portal veins.  It has also been successfully used in tumors of the head and neck, lung, retroperitoneum, kidney and prostate.  Martin et al (1) documented a doubling in survival in patients with locally unresectable pancreatic cancers from under 12 months (historical controls) to 24.9 months.  This procedure can be done both as an open surgical procedure and percutaneously by interventional radiology.   Nanoknife therapy provides a safe alternative therapy for patients with previously unresectable disease in the liver and pancreas.   With a short follow up, we have demonstrated effective local control.  Longer follow up and larger series are needed.

Aurora Health Care system has become the first site in Wisconsin to offer this new technology.  The procedural details, indications, patient selection and precautions will be presented along with case studies of patients undergoing this procedure.

Biography:

Birtukan Derso is BSC mid wife working in felegehiwot Referral hospital as a  midwife for the last 5 year and currently doing her second degree  in public health in Bahir Dar university .She has been a sole participant in many research activities undertaken in the region , especially in maternal and child health

Abstract:

Background: Intracranial tuberculoma in new born is a rare occurrence. We report a 7-month-old male infant presenting to our tertiary care referral center with complaints of global developmental delay and right hemiparesis for 3 months. Radiologic imaging was suggestive of large left frontoinsular space–occupying lesion with initial differential of primitive neuroectodermal tumor or desmoplastic infantile ganglioma. Considering the clinicoradiologic findings and no history suggestive of immunodeficiency or contact with tuberculosis, surgical decompression was done. Final histopathology revealed multiple epithelioid granulomas suggestive of tubercular etiology or intracranial Langerhans cell histiocytosis. He was started on antitubercular therapy after ruling out Langerhans cell histiocytosis using CD1a and Langerin immunohistochemistry staining. Interpretation of tuberculous etiology in infants can be challenging for clinicians, radiologists, and pathologists. A high index of suspicion is necessary to diagnose such lesions, predominantly in endemic regions.

Case Presentation: A 2500 gm neonate is born from a para-ii mother at a gestational age of 35weeks. The mother had only two antenatal follow up. In the last two months before delivery she had productive cough, shortness of breath, easy fatigability. Obstetric ultrasound showed normal pregnancy. Labor started in a week. She delivered 2800gm male with APGAR of 5 and 6in the 1st and 5th minutes. With widened anterior fontanel, increased tones of lower extremity of the right side and progressively fails to suck. With investigation the problem is found to be tuberculoma. The diagnosis, treatment and outcome of the case will be discussed in the presentation

Biography:

Sajid Iqbal have completed his predoctoral program in Biomedical Sciences from department of human genetics, KU Leuven University, Belgium. Currently working as Institution Research Manager with Emirates College of Technology, Abu Dhabi, U.A.E, Few of his publications are in international journals already.

Abstract:

Brest cancer (BC) is the second most widespread and the utmost common cancer among females population in the world. It has foremost influence on women health. Deaths from BC account for 1.6% of female deaths every year. The aim of this study was to determine the prevalence of BC, also to determine and quantify the associated risk factors for BC among Pakistani females. We carried out an observational case-control study for the present research. The study includes 105 BC patients and a group of 105 controls (healthy women). Univariate and multivariate logistic regression analysis along with Pearson’s Chi-square was applied to determine and quantify the association between risk factor and BC risk. In multivariate models, Environmental area and exposure to X-Ray radiations were found to be significantly associated with BC risk (p = 0.012, 0.03). Female with a positive family history of BC/ were at higher risk for developing BC. An early age at menarche was a strong risk factor for developing BC. Age less than 12 years increased the risk 2.551 times and an older age at menarche was associated with a significant reduction in the risk of BC. Menopausal status and age at last pregnancy were also risk factor of BC. We may conclude that the breast cancer is highly prevalent in the local population and its risk increases with X-ray radiation exposure, living area and habits, family history, early age of monarch and menopausal status.